在线名词解释大全 - 抗菌药物耐药性 - 详细

Q2–AmongthefollowingstatementsconcerningtheacquisitionofresistanceofGram-negativebacteriatoaminoglycosideswhichoneisNOTcorrect?

A
A.1 - Gram-negative bacteria acquire resistance to aminoglycosides by a mutation of the target.
B
B.2 - Gram-negative bacteria acquire resistance to aminoglycosides by synthesis of an aminoglycoside (AG)-phosphotransferase.
C
C.3 - Gram-negative bacteria acquire resistance to aminoglycosides because of the impermeability of the membrane.
D
D.4 - Gram-negative bacteria acquire resistance to aminoglycosides by the alteration of DNA replication.
正确答案:
Bacteria can express different resistance mechanism for a same class of antibiotics. Concerning aminoglycosides, the main resistance mechanism is due to the production of aminoglycoside modifying enzymes; however, a given strain could also express a mutated porin that impairs the entry of the drug and/or a mutated ribosomal protein.
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